In Diablo 4 there are many different material items you can find as you explore Sanctuary and this guide aims to show you the best places you can find those materials for your upgrading and crafting needs!
Herbs
These are quite probably the most essential materials you can find in Diablo 4. You can take plants to an alchemist to create a variety of elixirs that give you bonus XP, as well as other stat bonuses.
| Angelbreath | Greater Healing Potion Major Healing Potion Superior Healing Potion | Available nearly everywhere as interactive plants but is a rare drop. |
| Biteberry | Minor Healing Potion Light Healing Potion Major Healing Potion Weak Iron Barb Elixir Weak Elixir of Cold Resistance | Found in Fractured Peaks as a common drop in interactive plants. |
| Blightshade | Greater Healing Potion Major Healing Potion Superior Healing Potion Weak Elixir of Shadow Resistance | Found in Hawezar as a common drop in interactive plants. |
| Fiend Rose | Major Healing Potion Superior Healing Potion | Found during Helltide events whether in the environment or from slain enemies. |
| Gallowvine | Tiny Healing Potion Minor Healing Potion Light Healing Potion Moderate Healing Potion Strong Healing Potion Weak Iron Barb Elixir Weak Third Eye Elixir Weak Elixir of Cold Resistance Weak Elixir of Fire Resistance Weak Elixir of Lightning Resistance Weak Elixir of Poison Resistance Weak Elixir of Shadow Resistance Weak Assault Elixir Weak Crushing Elixir | Available nearly everywhere as interactive plants as a common drop. |
| Howler Moss | Moderate Healing Potion Major Healing Potion Superior Healing Potion Weak Third Eye Elixir Weak Elixir of Poison Resistance Weak Crushing Elixir | Found in Scosglen as a common drop in interactive plants. |
| Lifesbane | Greater Healing Potion Major Healing Potion Weak Elixir of Fire Resistance Weak Assault Elixir | Found in Kehjistan as a common drop in interactive plants. |
| Reddamine | Strong Healing Potion Greater Healing Potion Weak Elixir of Lightning Resistance | Found in Dry Steppes as a common drop in interactive plants. |
Ores
Upon reaching level 10 you unlock the blacksmith vendor, which is the vendor that will help you upgrade, repair, and salvage your gear from here on out. Ores are used as a means to upgrade your Diablo 4 Items, such as equipment and gear. There are numerous ore veins that you can find around Sanctuary. Interact with them to get more ore, which you’ll then use for your equipment.
| Iron Chunk | Available nearly everywhere as interactive ore veins. |
| Silver Ore | Available nearly everywhere as interactive ore veins. |
| Scattered Prism | Drops from Treasure Goblins and World Bosses. |
Skins
Skins are also crucial for upgrading gear. The key difference is that they’re used exclusively for pieces of armor. Getting them is simple but the sources for skins aren’t as abundant as other resources in the game.
| Rawhide | Obtained from the various wildlife and beasts in Sanctuary. |
| Superior Leather | Obtained from the various wildlife and beasts in Sanctuary. |
Monster Parts
Like plants, monster parts are mainly used for alchemy and potion purposes. The main difference is that to find monster parts, you’ll need to fight and kill certain enemies in the game. Luckily, they’re all basic enemies to slay.
| Demon’s Heart | Found by slaying demon-type enemies. | Focus on demon-infested areas like in Kehjistan. |
| Crushed Beast Bones | Found by slaying beasts, animals, and werecreatures. | Best farmed in the Highlands Wilds area near Under the Far Goose Inn Waypoint. From the waypoint, take the west route and look for spiders and bears that can drop the item. |
| Gravedust | Found by slaying skeletal enemies, as well as interacting with corpses and skeletons around the world. | Look for graveyards in Sanctuary. Also great to farm inside dungeons. |
| Paletongue | Found by slaying humanoid-type enemies. | Walk around Dry Steppes and Hawezar. Both areas contain a lot of humanoid-type enemies. |
Salvage Parts
Once you start upgrading your gear, you’re going to need salvage parts as well. As the name suggests, you can get most salvage parts by salvaging other items. Salvaging Legendary, Sacred, and Ancestral items might seem wasteful but keep in mind that you’re going to get better gear in the long run. As such, you could use more salvage materials instead. If you really like the Aspect of a certain gear, just extract it instead of salvaging the gear for parts.
| Abstruse Sigil | Rare crafting material used for improving legendary jewelry. | Acquired by salvaging Legendary-rarity Jewelry. |
| Baleful Fragment | Rare crafting material that is used for upgrading Legendary gear. | Acquired by salvaging Legendary-rarity weapons. |
| Coiling Ward | Rare crafting material that is used for upgrading Legendary gear. | Acquired by salvaging Legendary-rarity armors. |
| Forgotten Soul | Rare crafting material that is used to upgrade Sacred and Ancestral-rarity gear. | Can drop during Helltide Events. |
| Sigil Powder | Rare Crafting Material that is used for creating Nightmare Sigils. | Acquired by salvaging Nightmare Sigils of any tier. |
| Veiled Crystal | Rare crafting material that is used in the Occultist for Legendary Aspects and Imprinting. | Acquire by salvaging gear with Rare rarity and above. |